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In preliminary findings from preclinical studies, concurrent therapy with GLP-1RAs and SGLT-2is may change intestinal microbial biology in distinctive or synergistic ways

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Similarly intra-NAc core GLP-1 administration at a dose that reduced chow intake did not elicit a conditioned taste aversion to saccharine, indicating that the rats did not find the accumbal GLP-1R stimulation aversive (Dossat et al., 2011)

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The Bottom Line GLP-1 medications can be a helpful tool, but they work best when paired with intentional nutrition and strength-focused habits

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It was part of my journey to learn to let go of scarcity mindset around food

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It's also important to be aware of serious conditions that require urgent evaluation regardless of medication expiration status, including severe abdominal pain radiating to the back (possible pancreatitis) or persistent right upper quadrant pain, fever, or jaundice (possible gallbladder disease)both known risks with GLP-1 receptor agonists

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