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Sjgrens syndrome SS is a chronic autoimmune disorder that predominantly impacts the exocrine glandular system, particularly the lacrimal and salivary glands

CL and JL contributed to the literature search, data extraction and quality assessment

Preclinical studies have found that Ex-4 significantly upregulates Sirt3 expression in glioblastoma by activating the GLP-1R, which subsequently inhibits the growth, migration, invasion, and epithelial-mesenchymal transition of glioma cells [87]

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Providers should consider baseline gastric emptying studies in high-risk patients and educate all patients to promptly report new or worsening GI symptoms to prevent complications like acute kidney injury or malnutrition

Many people experience significant weight loss, reduced appetite, and improved metabolic health