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The use of classes, rather than historical descriptions (such as severe or morbid), also avoids the use of stigmatising language, not least given the prevalence and negative consequences of weight stigma both in society 28 and amongst medical professionals 29
Similarly, Karen stated she had "never seen anyone lose weight for good without prescription meds" , underscoring how impactful GLP-1 therapy can be for long-term success

Thigh (front of the upper leg): midway between hip and knee

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Outlook: Will compounding remain important in H2 2025 and 2026
