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Semaglutide is not metabolized by the liver's cytochrome P450 enzyme system

[6] Preclinical studies in animal models suggest that GLP-1 receptor activation may: Promote neuroplasticity and neurogenesis (formation of new neurons) in the hippocampus, a region often showing reduced volume in depression Modulate neurotransmitter systems , particularly dopamine and serotonin pathways involved in mood regulation and reward processing Reduce neuroinflammation , which is increasingly recognised as contributing to depressive disorders Enhance brain-derived neurotrophic factor (BDNF) expression, a protein crucial for neuronal health and resilience Metabolic improvements associated with GLP-1 therapy may also contribute indirectly to mood benefits

However, dissecting the weight loss-dependent and independent mechanisms of bariatric surgery in humans is highly challenging as long-term control of food intake is not possible

Khan has several years of expertise in treating patients with diabetes and obesity

In contrast, the glucagon component provides its thermogenic and lipolytic benefits without clinically significant hyperglycemia

Dhatariya K, Bain SC, Buse JB, Simpson R, Tarnow L, Kaltoft MS, Stellfeld M, Tornoe K, Pratley RE