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Description
Really interesting findings and very aligned with what many of us are seeing

Results vary based on individual health, adherence to treatment, and lifestyle factors

In rats, GLP-1 (7-36amide) and, perhaps paradoxically, the GLP-1R antagonist exendin (939), dose-dependently cause relaxation of the aorta, potentially via elevation of cAMP formation and activation of K ATP channels [624]

Six to eight-week-old female SD rats (about 160 g) were anesthetized

Failure to account for these sources of variation conflates genuinely unresponsive patients with those who receive inadequate formulation exposure or are otherwise mismatched to the intervention

Heitmann BL
