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[DOI] [PubMed] [Google Scholar] [43].Johansen NJ, Dejgaard TF, Lund A, et al

However, adverse gastrointestinal effects generally preclude the use of higher doses, even with adjusted uptitration dosing algorithms [734,877]

Enter John Eng, a physician-researcher working at the James J
Int J Obes 37(11):14431451

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Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy