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In this paradigm, the total daily food consumption of lean and healthy adult animals remained stable over several weeks on a level that clearly avoided overconsumption and covered their homoeostatic needs [34]

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If interventions are not started, the increased demand for insulin can overload pancreatic -cells leading to pancreatic -cell failure, decreased insulin secretion, and uncontrolled glycemia (Figure 1)

Glickman suggests

doi: 10.1007/s00125-016-3874-y, 37 FeinglosM