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SC semaglutide significantly attenuates aortic plaque lesions in nondiabetic low-density-lipoprotein-receptor-deficient mice in a dose-independent manner and affects genes related to atherosclerosis [50]

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Additionally, these medications are covered for the treatment of childhood obesity under Medicaids Early and Periodic Screening, Diagnostic and Treatment (EPSDT) benefit

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For example, while the SUSTAIN-6 study included patients with proliferative DR (PDR) and diabetic macular edema (DME), other CVOTs, such as PIONEER 6, did not