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Dose splittingdividing your weekly injection into two smaller dosesis a clinically recognized strategy to improve tolerability while maintaining therapeutic benefit

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Both participants and investigators were blinded to treatment assignment

Methods A systematic literature search was conducted on PubMed and Embase (Ovid) databases using the search terms GLP-1 and pain

Despite significant heterogeneity in insulin and semaglutide receptor profiles based on ethnicity, age, sex, obesity diagnosis, cardiovascular disease , and Alzheimers risk factors, these groups were balanced using propensity score matching