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Also, as an anabolic hormone, insulin promotes fat storage, and chronic hyperinsulinemia, commonly observed in T2DM, further stimulates lipogenesis while suppressing lipolysis, thereby counteracting BW reduction

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The frequency of nausea displayed by patients shows dose dependency because the occurrence approximately doubles when higher doses of the same medication are administered compared to lower doses

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Uninsured or underinsured patients may qualify for patient-assistance programs that offer medication at low or no cost

Despite their significant clinical potential, they are associated with certain limitations, including suboptimal pharmacokinetics and patient adherence challenges, necessitating the development of advanced drug delivery systems to optimize efficacy and improve compliance