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Orforglipron (LY3502970), a novel, oral non-peptide glucagon-like peptide-1 receptor agonist: a phase 1b, multicentre, blinded, placebo-controlled, randomized, multiple-ascending-dose study in people with type 2 diabetes

with insulin and GLP-1 and GIP analogues) has been associated with temporary worsening of diabetic retinopathy (disease of the retina secondary to diabetes)[19]

Prediabetes, indeed, presents an annual conversion rate to T2D of about 510% [32]

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The use of lorcaserin did not increase the rate of cardiac valvulopathy among the 2472 patients evaluated after 1 year and 1127 evaluated after 2 years

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