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Additionally, it effectively reduces food cravings, giving individuals greater control over their dietary choices

Patients receiving semaglutide also had greater reductions in bodyweight, waist circumference, body mass index, and glycated hemoglobin

Most patients notice appetite suppression within the first 1-2 weeks

2023;14(August):116

In addition to acting on other metabolically relevant tissues, vagal afferents contain TLR4 263 , and LPS impairs gutbrain vagal signaling 264,265

New England Journal of Medicine: Retatrutide Phase 2 trial results - The landmark study establishing retatrutide efficacy and safety across multiple dose groups New England Journal of Medicine: STEP 1 semaglutide trial results - The pivotal trial demonstrating semaglutide 2.4 mg weight loss efficacy ClinicalTrials.gov: Retatrutide TRIUMPH program - Current status and details of all ongoing Phase 3 retatrutide trials FDA prescribing information for Wegovy (semaglutide 2.4 mg) - Complete approved labeling including dosing, safety, and clinical data New England Journal of Medicine: SELECT cardiovascular outcomes trial - The trial demonstrating semaglutide 20% reduction in major cardiovascular events These primary sources should be the foundation for any serious evaluation of either compound