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Its this: losing weight on a GLP-1 means losing a meaningful proportion of lean tissue alongside fat, unless you take specific steps to preserve it
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Collectively, intestinal NAMPT-mediated NAD + biosynthesis contributes to Wnt signaling, maintaining intestinal homeostasis, including GLP-1 production and postprandial glucose homeostasis (Figure 3)
These effects were coupled to an amelioration in lipid metabolism and hepatic steatosis, which markedly exceeded the effect of single GLP-1RA treatment ( Oxyntomodulin, a gut-derived peptide hormone, activates both the GLP-1R and the GCGR, although, with reduced affinity compared to GLP-1 and glucagon, respectively
The effect of exenatide on thyroid-stimulating hormone and thyroid volume
