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Although this large, rigorous trial can provide support for a potential new indication for semaglutide for secondary prevention of CVD, whether and how quickly payers may reimburse for such an indication is uncertain

Adipose tissue, particularly visceral fat, is metabolically active and secretes pro-inflammatory adipokines

For diabetes patients, A1c reductions of approximately 1.0-1.5 percentage points are common with GLP-1 receptor agonists, while tirzepatide has shown reductions of up to 2.0-2.3 percentage points in clinical trials

Effects of weight loss interventions for adults who are obese on mortality, cardiovascular disease, and cancer: systematic review and meta-analysis