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The recent BMJ systematic review and meta-analysis that triggered many of these headlines is important and, frankly, not surprising to clinicians who understand obesity as a chronic, relapsing disease

Weight loss varies by medication, dose, adherence, side effects, nutrition, activity, sleep, and medical history

10.1194/jlr.M044669 333

23 The proposed mechanisms through which obesity can impact male factor subfertility are summarised in Figure 2

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To address this, logic-gated CAR designs have been developed, in which T cell activation requires the co-expression of PD-L1 together with another tumor-specific antigen, thereby improving selectivity