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With semaglutide medications, people lose an average of 13.7-15.1% of their starting body weight

A 2025 bioRxiv preprint from Yale found that semaglutide alters the dopamine signals surrounding exercise in animal models, which complicates the simple narrative that the drug straightforwardly increases or decreases motivation to move

Kim, Y.K

While some experience increased energy, others struggle with fatigue

If hot flushes disrupt sleep, put a cold-water bottle at the foot of the bed and schedule a 10-minute wind-down routine 30 minutes before lights out to lower baseline arousal