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While mothers were asked to report any infant adverse effects, long-term follow-up of the exposed infants would provide more comprehensive understanding of potential risks

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Notably, the majority of mechanistic data supporting this concentration-dependent model derives from preclinical studies using mouse pancreatic -cells and clonal cell lines, with limited validation in human islet studies, necessitating further clinical investigation to confirm these concentration thresholds in human diabetes treatment [23,24,25,26]

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