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In Re: Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAs) Non-Arteritic Anterior Ischemic Optic Neuropathy Products Liability Litigation , MDL 3163, currently has 29 plaintiffs alleging that GLP-1 RA drugs caused them to develop non-arteritic anterior ischemic optic neuropathy (NAION)

Your doctor may reduce doses of those medications when starting a GLP-1

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Dipeptidyl peptidase-4 inhibitors and the management of type 2 diabetes mellitus

GPs are being encouraged to talk to patients about the safety of unapproved weight-loss medications, following new concerns over unregistered GLP-1 products being promoted online

Furthermore, exendin-4 can stimulate the cyclic adenosine monophosphate/protein kinase A (cAMP-PKA) pathway by activating GLP-1R, which then increases the level of non-phosphorylated -catenin to stimulate the Wnt/-catenin/NeuroD1 pathway and inhibits the activity of GSK-3, ultimately decreasing the hyperphosphorylation of AD-associated tau proteins regulated by GSK-3 (Reich and Hlscher, 2022)