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Leptin resistance, commonly found in obese women, is likely to blunt the peri-ovulatory anorexigenic effect of estradiol

Eat smaller meals more slowly and avoid high-fat or highly acidic foods such as caffeinated beverages, tomatoes, and citrus fruits.

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This raises the possibility that blood alcohol concentrations may differ between drug- and vehicle-treated animals, potentially contributing to the observed disruption in discrimination