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To our knowledge, this is the first reported case suggesting the potential role of GLP-1 receptor agonists in slowing the progression of localized scleroderma, possibly due to their anti-fibrotic and anti-inflammatory effects.

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This article covers mechanism, clinical trial evidence, FDA-approved indications, boxed-warning safety, and the FTO, GLP1R, MC4R, and TCF7L2 variants that shape every GLP-1 response