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A deeper understanding of the gutmicrobiomebrain axis may ultimately enable personalized, microbiota-guided therapies that treat both the physiological and psychological dimensions of obesity and depression, marking a major step toward holistic and precision medicine.

However, the triagonist failed to enhance insulin secretion in islets lacking both Glp-1r and Gipr and upon treatment with the GLP-1 receptor-specific antagonist exendin-3 (939)

A study found that people with lower appetite-regulating hormone levels responded better to tirzepatide

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