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Stereochemical inversion as a route to improved biophysical properties of therapeutic peptides exemplified by glucagon

8 , bvae116 (2024)

Abstract Recent large clinical trials on sodium-glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists, with the aim of verifying cardiovascular safety, have revealed that these medications have a preventative advantage on adverse cardiovascular outcomes, including worsening of heart failure and deterioration of nephropathy, in patients with type 2 diabetes (T2D)

PMID: 38599221

[13] performed a systematic review and meta-analysis to investigate this association, showing that patients with diabetes were at increased risk of cancer by approximately 20%

Most headaches resolve within the first two to four weeks on a stable dose