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Yet 6 to 7 weeks of daily treatment with semaglutide (escalated from 41 g/kg to 103 g/kg) or tirzepatide (escalated from 12 g/kg to 48 g/kg) did not produce any noticeable effect on these readouts, including Iba-1 activation, in 12-month-old 5XFAD and APP/PS1 mice (51)

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Clinical perspectives on the use of the GIP/GLP-1 receptor agonist tirzepatide for the treatment of type-2 diabetes and obesity

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The Purity Problem: When you're stacking compounds, the purity of each component becomes exponentially more important