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since hydroxycarbamide is mainly removed from the body by the kidneys, any reduction in kidney function can cause hydroxycarbamide to build up to dangerous levels

10.1056/NEJMoa1603827 66 MeierJ

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13.4 Dehydration and Electrolyte Imbalance Risks 13.5 Visual Changes and Diabetic Retinopathy Concerns Rapid improvements in glycemic control may transiently worsen diabetic retinopathy

In one study, people who combined a GLP-1 medication with supervised exercise were more likely to maintain at least 10% weight loss one year after stopping treatment compared with those who used medication alone

Adequate sleep, proper nutrition, and B12 supplementation may help