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With regard to nicotine use disorder, exendin-4 (2.4 g/kg) pretreatment reduced nicotine-induced locomotion, sensitization, CPP and accumbal dopamine release [187]

doi: 10.1001/jama.2023.19897

W., Walker, A

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Typical semaglutide escalation follows a pattern: 0.25 mg for weeks 1 through 4, then 0.5 mg for weeks 5 through 8, then gradual increases toward the target dose of 1.0 to 2.4 mg depending on response and tolerance

S., Pharmacotherapy of Obesity: An Update on the Available Medications and Drugs Under Investigation, EClinicalMedicine 58 (2023): 101882, 10.1016/j.eclinm.2023.101882