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A proportion of participants also discontinued GLP-1 RA therapy after 3 years and it is well described that individuals can re-gain two-thirds of their initial weight loss upon cessation of GLP-1 RA [44]

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Compounded medications are easily available during drug shortages and are affordable for most patients

HFpEF is often accompanied by excess fat around the heart, called epicardial adipose tissue (EAT)

The extracellular androgen receptors, which are activated by DHT in cells, enhance glucose-stimulated insulin secretion (GSIS) by increasing islet cAMP and activating protein kinase A [76]

J Med Chem 43:16641669 Ostawal A, Mocevic E, Kragh N, Xu W (2016) Clinical effectiveness of liraglutide in type 2 diabetes treatment in the real-world setting: a systematic literature review