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Although the FLOW trial and the secondary analysis of the SELECT trial have demonstrated important kidney benefits of semaglutide, the kidney-protective effects of other GLP-1 receptor agonists are less well known, as there have not been prospective trials with kidney outcomes, and it is unclear whether the benefits of these medications are a class effect or are medication specific

They are most prevalent during or shortly after dose escalation and decrease afterwards

Therefore, using a large, real-world population with type 2 diabetes, we constructed a model to assess the cost-effectiveness of widespread use of SGLT2is and GLP-1 RAs in people with type 2 diabetes, considering only major cardiovascular and kidney outcomes

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10.1080/19382014.2015.1045182 80 PriyadarshiniM.VillaS

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