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On Monday night, Oprah Winfrey aired her latest prime-time special, Shame, Blame and the Weight Loss Revolution

However, clinical studies have shown promising results: Average Weight Loss: Clinical trials indicate that people using GLP-1 for weight loss typically lose around 15-20% of their body weight over a period of 68 weeks (approximately 1 year and 3 months), when combined with a reduced-calorie diet and increased physical activity

Other GLP-1s like dulaglutide (Trulicity) and liraglutide (Victoza) also help reduce protein urea and improve kidney function, but semaglutide has the strongest evidence

Safe Alternatives for Body Composition Goals Achieving optimal body composition for bodybuilding is best accomplished through evidence-based, sustainable methods that do not involve pharmaceutical interventions intended for disease management

Weekly injections of semaglutide (2.4 mg) added to lifestyle changes resulted in clinically relevant weight loss for overweight or obese adults without diabetes

So now you see many commercials about versions that are recently approved for weight loss, such as Wegovy for semaglutide and Zepbound for Tirzepatide