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GIP receptor activation also appears to have independent effects on fat metabolism and energy expenditure

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Managing GLP-1 Side Effects: Our Top Tips for Success GLP-1 agonists, like semaglutide and tirzepatide, are groundbreaking treatments for managing type 2 diabetes and obesity

(Pharmacogenomics) The heritability of GLP-1 release is around 50%.[ref] Thus, while there is a fairly important genetic component, diet is also really important