semaglutide for prediabetes Efficacy and safety of once-weekly 2·4 mg versus placebo in people with obesity and (STEP 10): a randomised, double-blind, placebo-controlled, multicentre phase 3 trial Semaglutide 2.4 mg clinical outcomes
Description
The NDA for Wegovy was submitted in December 2020, before the pivotal trial was even published

Research reveals patients shed a significant amount of weight, up to 24.2% at 48 weeks, and skin sagging was lower than anticipated

doi: 10.1016/S2213-8587(24)00272-9

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NICE guidance requires specialist initiation, specific BMI criteria, weight-related comorbidities, and treatment as part of comprehensive lifestyle programmes

Plans may also impose quantity limits or step edits (e.g
