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Treatment of diet-induced obese mice with sitagliptin (4 g/kg), a DPP-4 inhibitor, significantly reduced the expression of inflammatory genes including monocyte chemotactic protein- (MCP-) 1, IL-6, IL-12(p40), IL-12(p35), and IFN- -induced protein 10 (IP-10) in pancreatic islets and improved glucose-stimulated insulin secretion in isolated islets [19]
Baseline eGFR and UACR values in these studies suggest that participants were not predominantly at high-risk for CKD progression [80,81]
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A review of the evidence on their effects on hepatocellular carcinoma
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A single early dose does not accelerate weight loss or improve blood sugar control
