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In a pilot study carried out around 20002001, Jeppesen and colleagues demonstrated that native GLP-2 administered twice daily for 35 days increased nutrient absorption, energy absorption, and weight gain in human subjects with SBS (66)

Demonstrating cardiovascular benefits in the SELECT trial establishes these agents as potentially life-saving interventions

Setting UK Clinical Practice Research Datalink linked to Hospital Episode Statistics Admitted Patient Care and Office for National Statistics databases

Both studies found that people who took GLP-1s had worse vision outcomes than those who did not

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However, endogenous GLP-1 has an extremely short half-life due to rapid degradation by dipeptidyl peptidase-4 and renal clearance