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The real significance is that it may help bring effective metabolic therapy to many more people

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Electronic databases including PubMed, Embase, and Web of Science were searched from inception until August 2025 using keywords such as GLP-1 receptor agonist, diabetic retinopathy, glaucoma, age-related macular degeneration, ocular disease, and neuroprotection. The search focused on identifying preclinical studies, large-scale retrospective cohort studies, and post-hoc analyses of major clinical trials that evaluated the utility and potential mechanisms of GLP-1RAs in ophthalmic diseases

Tirzepatide (TZP), a dual GLP-1/GIP receptor agonist, is recognized for its potent glycemic and weight-lowering effects, yet its influence on hepatic mitochondrial dynamics in diabetes remains unclear

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