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So a simple superposition of any one of the NMR models (PDB ID 4apd) in the Semaglutide bound GLP-1R structure (PDB ID 7ki0) is unlikely to show the specific interactions of Liraglutide and the receptor and is not shown here

10.1073/pnas.1218051109 67 KleinS.SheardN

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Additionally, tirzepatide did not attenuate the reduction of sleeping metabolic rate or 24-h sedentary energy expenditure in comparison to baseline (though not significantly different than placebo), but significantly increased fat oxidation and decreased carbohydrate and protein oxidation as compared to placebo [57]

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Patients with a history of allergic reactions or sensitivities to GLP-1 receptor agonists, pancreatitis, thyroid cancerincluding medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN-2) generally are not suitable candidates for this therapy