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Animal model studies consistently demonstrated that semaglutide can significantly alter gut microbiota, suggesting that part of semaglutides metabolic benefit may derive from its capacity to modulate inflammation via gut-immune-microbiota interactions and to correct dysbiosis induced by high-fat diets [82, 84]

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Mounjaro body aches affect fewer than 1 in 100 patients directly (uncommon myalgia), while 5-10% experience muscle pain from GI-induced dehydration and electrolyte loss during rapid weight loss