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Enzymes and stomach acids break down proteins quickly, meaning only a tiny fraction of an oral dose is successfully absorbed into systemic circulation

Zepbound tirzepatide injection, commonly used for chronic weight management

The answer explains nearly everything else, from how much weight people lose to which side effects appear to what metabolic benefits extend beyond the scale

Interestingly, the plasma concentration achieved with once-weekly exenatide ER is comparable to that of a single injection of immediate-release exenatide (Byetta) [60, 61]
