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GLP-1 receptor agonists carry a boxed warning about thyroid C-cell tumors based on animal studies with liraglutide

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Although liraglutide treatment led to a decrease in pro-inflammatory microbial species (e.g., EscherichiaShigella, Megamonas , and Bacillus ) in DM2 patients, no statistically significant differences were observed when compared to metformin treatment

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Clinical Evidence on Post-Ozempic Weight Rebound Rates The STEP trials, which established Ozempic's efficacy for weight loss, also documented rebound patterns after discontinuation

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