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GLP-1 agonists can also increase satiety, reduce feelings of hunger, delay gastric emptying, decrease food cravings, and result in an improvement in eating control

There is ongoing work in this area, including elucidating the modulatory effects of liraglutide on the EAT microenvironment (NCT03260881) (Table 3)

39 Serving smaller amounts initially, knowing one can always have a little more if genuinely still hungry after a pause

When to seek medical advice : Patients should contact their GP or diabetes specialist nurse if they experience: Severe, persistent vomiting preventing adequate fluid intake (risk of dehydration and acute kidney injury) Severe abdominal pain, particularly if radiating to the back (potential pancreatitisrare but serious) Right upper abdominal pain, fever, or yellowing of skin/eyes (potential gallbladder disease) Sudden vision changes (particularly with semaglutide, which may worsen diabetic retinopathy, especially with rapid HbA1c reduction) [40] [41] Signs of hypoglycaemia when used with insulin or sulphonylureas Allergic reactions (rash, difficulty breathing, facial swelling)call 999 or go to A&E for severe allergic reactions Patients should report suspected side effects via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk or the Yellow Card app)