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Cardiovascular effects represent a primary concern

Exclusivities at Approval Drug manufacturers listed 164 patents across the 10 products that were filed before FDA approval with a median of 17 patents per product (interquartile range [IQR]: 8.3-22.8)

Meyhfer, Jens Aberle: The authors have received honoraria for speaking at symposia, financial support for attending symposia, financial support for educational programs, and consultation from Novo Nordisk

For type 2 diabetes, most guidelines recommend continuing metformin as foundational therapy

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It increases inflammation, worsens insulin resistance, and raises long-term cardiovascular risk
