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Conclusions Patients with T2D starting tirzepatide had greater HbA1c and weight reductions at 12 months post-initiation than those on injectable semaglutide, regardless of previous GLP-1 RA use, consistent with previous clinical trial results.

Differences between GLP1RAs in pharmacokinetics, dosing regimens and clinical effects, including cardiovascular (CV) ...
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The doctor's greater concern, she said, is not the drug itself but how patients obtain it.

From nausea and exhaustion to emotional shifts and social awkwardness, people on GLP-1 medications are sharing the side effects they didn't expect and rarely see talked about.
