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Tirzepatide targets both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors, enhancing appetite suppression and promoting a broader metabolic response

A systematic review and meta-analysis evaluating lifestyle-based weight loss interventions in adults with T2D demonstrated their significant efficacy in weight management and glycemic control [358]

In rabbits, resorptions, decreased litter size, and decreased fetal weights were observed at maternally toxic doses, at systemic exposures greater than 8 times higher than exposure at the approved human dose of PAXLOVID

A strict keto diet is not required, but reducing refined carbohydrates is highly beneficial
