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This review has deliberately distinguished failed biology from failed pharmacology, emphasizing that genuine on-target toxicity, repeated lack of efficacy in well-designed human studies, or insurmountable technical barriers justify abandonment

However, like most therapies targeting metabolic pathways, they are not free of risks

These trials are mostly based on composite reductions in MACEs (similar to the original ELIXA trial endpoint)

Cushing's disease and idiopathic intracranial hypertension: case report and review of underlying pathophysiological mechanisms

These adverse events lead some patients to discontinue therapy before achieving optimal clinical outcomes, reducing long-term treatment adherence