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Performance of the UK prospective diabetes study outcomes Model 2 in a contemporary UK Type 2 Diabetes Trial Cohort
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J Am Soc Nephrol (2006) 17(7):195061
Subgroup meta-analyses based on participants kidney function indicated that the salutary effects of SGLT2i on MACE, cardiovascular death or HHF, and a composite kidney outcome (substantial loss of kidney function, end-stage kidney disease or death due to kidney disease) do not significantly differ among subgroups based on eGFR [142, 252]
Persistent hyperglycaemia induces deleterious changes in kidney cellular metabolism and function through a variety of mechanisms
