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The dose-findings studies reported here not only documented the superior efficacy of GLP1/E in the management of metabolic alterations in our obese PCOS model, including lowering body weight and adiposity, as well as improvement of glucose handling and insulin resistance, but also highlighted a non-monotonic effect of this dual agonist in PNA mice, with optimal effects being achieved with submaximal doses

Regulatory support from agencies like the FDA has accelerated the approval of new therapies, enhancing market dynamics

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Nat Rev Cardiol 20(7):463474

doi: 10.5607/en.2017.26.4.227 [DOI] [PMC free article] [PubMed] [Google Scholar] 133