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This magnitude of body weight reduction had not been reported to date in any other phase 2 or 3 trials testing weekly GLP-1RA or GLP-1R/GIPR dual agonists in patients living with T2DM, potentially due to the additional agonism of the glucagon receptor (Grunberger et al

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Another study evaluating the 24-week efficacy of oral semaglutide in 25 patients with T2DM aged 2078 years reported preservation of lean mass and appendicular skeletal muscle mass index (ASMI), along with reductions in fat mass