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Yes, simethicone simply breaks the surface tension of trapped gas bubbles so you can pass them naturally, and it will not interfere with how acid reducers like Pepcid or Prilosec work
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PMID: 21209017
J.ShihY.-H.HsuC
123 Besides, synaptic plasticity-related proteins, including CREB, pCREB, brain-derived neurotrophic factor (BDNF), and activity-regulated cytoskeleton (Arc) proteins, are significantly reduced

The worldwide epidemiology of type 2 diabetes mellitus[mdash]present and future perspectives
