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Robustness was greater for inverse associations, with E-values of 5.70 for pemphigus (HR 0.32) and 2.66 for bullous pemphigoid (HR 0.61), indicating that comparatively strong residual confounding would be necessary to nullify these findings

DiscoverX Cell Signaling Assays For the cAMP assay, cAMP HitHunter hGLP1R-CHO-K1 cells (DiscoverX, Fremont, CA) were seeded in a total volume of 20 L into white walled, 384-well microplates and incubated at 37 C

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Gradual dose titration of GLP-1 medications, as per manufacturer recommendations, helps minimise gastrointestinal side effects
