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For a deeper dive into related GLP-1 side effects, read our guide to why GLP-1 medications cause GI issues
Unlike other diabetes medications that require frequent subcutaneous injections, Rybelsus is taken orally each morning
These agents work by stimulating insulin secretion in a glucose-dependent manner, suppressing glucagon release, slowing gastric emptying, and promoting satiety through central nervous system pathways

Br J Pharmacol 155(7):10851092 Guan Q (2019) A comprehensive review and update on the pathogenesis of inflammatory bowel disease
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[DOI] [PubMed] [Google Scholar] 111.Rizvi AA and Rizzo M, The Emerging Role of Dual GLP-1 and GIP Receptor Agonists in Glycemic Management and Cardiovascular Risk Reduction, Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 15 (2022): 10231030