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Safety data in special populationssuch as pregnant or lactating women, pediatric patients, and those with advanced renal or hepatic impairmentremain limited and require further study

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8,37 Secondary endpoints in STEP-HFpEF DM, including changes in 6-minute walk distance and body weight, also favoured semaglutide

TBARS, Thiobarbituric Acid Reactive Substances (a marker of oxidative stress), TGF1, Transforming Growth Factor Beta 1, TNF-, Tumor Necrosis Factor-Alpha, UAC/U-Alb, Urinary Albumin-to-Creatinine Ratio/Urinary Albumin

Furthermore, early safety trials that included kidney outcomes as secondary endpoints hinted at potential renal benefits associated with these medication classes

[5] [6] Immune function is not directly suppressed by GLP-1 agonists, which is reassuring for patients with lymphoproliferative disorders who may already have compromised immunity