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Given that both GIP receptor agonism and antagonism have only been thoroughly investigated in combination with GLP-1 receptor agonism, long-term clinical studies of GIP receptor antagonism alone are needed to evaluate the adverse effect profile

Realistic goal-setting is crucialmaintaining even 5-10% weight loss provides significant health benefits, even if it represents partial regain from peak weight loss

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In a mouse model of non-alcoholic fatty liver disease-associated HCC (207), liraglutide prevented HCC progression by modulating blood glucose levels and ameliorating steatosis and inflammation in non-tumorous liver lesions

In Wilding and colleagues' STEP 1 trial, semaglutide produced a mean loss of about 15 percent of body weight over 68 weeks